Research Scientist I

The Ivy Brain Tumor Center at Barrow Neurological Institute is a non-conventional non-profit program offering state-of-the-art clinical trials for patients with the most aggressive form of brain cancer. It is home to the largest collection of Phase 0 trials for brain tumors in the world. Our multidisciplinary team of brain tumor specialists and scientists are accelerating drug discovery and precision medicine in neuro-oncology to identify the most promising first-in-class therapies for brain tumor patients.

To facilitate the development of brain targeting therapeutics via neuro-pharmacokinetic characterization of various molecules through preclinical and clinical studies. Principal Duties and Responsibilities: We are looking for an individual to join the Pharmacokinetics (PK) Lab as a Research Scientist. The candidate should have a strong background in chemical/pharmaceutical sciences with a strong research experience in translational studies. Candidates should demonstrate significant experience in LC-MS/MS-based method development and validation in compliance with CAP/CLIA regulations and/or FDA guidelines and competency in pharmacokinetic data analysis. The candidate should be able to work well in highly collaborative environment and have excellent communication skills. Potential areas of application include bioanalysis method validation drug development drug pharmacokinetics biomarker analysis and PK modeling.

Key responsibilities include 

Development validation and implementation of analytical methods for various drugs drug candidates metabolites and biomarkers employing UHPLC and LC-MS/MS techniques.

Planning and conducting preclinical pharmacokinetic studies including drug formulations administration through various routes tissue perfusion harvesting and analysis.

Performing biochemical and physicochemical characterization of various molecules.

Performing pharmacokinetic data analyses and interpretation.

Oversight and implementation of multiple research projects.

Facilitates research activities in partnership with laboratory PI leveraging scientific experience.

Manuscript preparation and publishing.

Development of research projects assistance with grant proposals and applications.

Supervision and training of laboratory personnel including post-doctoral fellows PhD and undergrad students.

Preparation and delivery of research presentations at local meetings national and international conferences.

General operation maintenance and troubleshooting of lab equipment including UHPLC and LC-MS/MS.

Preparation and maintenance of required laboratory safety documentation and adherence to the guidelines and regulations in compliance with CAP/CLIA regulations and FDA guidelines.

Preferred Qualifications:

Postdoctoral training (5+ years) in bioanalysis pharmacology medicinal or pharmaceutical chemistry areas.

Proven record of UHPLC or LC-MS/MS-based assay development and validation in compliance with CAP/CLIA regulations and/or FDA guidelines.

Experience in pharmacokinetic study design execution data analyses and interpretation.

Experience in biomedical research (cellular techniques and preclinical efficacy studies).

Experience with maintenance and troubleshooting of LC and MS systems.

Excellent organizational and analytical skills.

Ability to work independently and cohesively as part of a team.

Additional Requirements Recommendation letters Education Ph.D. or equivalent degree (MD DVM PharmD etc.) in Pharmaceutical Sciences Chemistry Biochemistry Medical Sciences or in related disciplines.

MD or Ph.D. upon hire Required

Doctor Of Medicine MD or Ph.D in Epidemiology upon hire and Five (5) years or equivalent of research-related experience and data analysis following the Ph.D. or M.D. degree

Experience with a statistical package (R or Stata) preferred

Specialized computer analysis program experience preferred

Hello humankindness Located conveniently in the heart of Phoenix, Arizona,St. Joseph's Hospital and Medical Center is a 571-bed, not-for-profit hospital that provides a wide range of health, social and support services. Founded in 1895 by the Sisters of Mercy, St. Joseph's was the first hospital in the Phoenix area. More than 125 years later, St. Joseph's remains dedicated to its mission of caring for the poor and underserved. We are extremely proud to be a nationally recognized center for quality quaternary care, medical education and research. St. Joseph's includes the internationally renowned Barrow Neurological Institute, Norton Thoracic Institute, Cancer Center at St. Joseph's, Ivy Brain Tumor Center, and St. Joseph's Level I Trauma Center (which is verified by the American College of Surgeons). The hospital is also a respected center for high-risk obstetrics, neuro-rehabilitation, orthopedics, and other medical services. St. Joseph’s is considered a sought-after destination hospital for treating the most complex cases from throughout the world. Every day, approximately 20 percent of the hospital’s patients have traveled from outside of Arizona and the United States to seek treatment at St. Joseph’s. U.S News & World Report routinely ranks St. Joseph's among the top hospitals in the United States for neurology and neurosurgery. In addition, St. Joseph's boasts the Creighton University School of Medicine at St. Joseph's, and a strategic alliance with Phoenix Children's Hospital. St. Joseph's is consistently named an outstanding place to work and one of Arizona's healthiest employers.

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