Postdoctoral Fellow in Pharmacokinetics Laboratory

The Ivy Brain Tumor Center at Barrow Neurological Institute is a non-conventional, non-profit program offering state-of-the-art clinical trials for patients with the most aggressive form of brain cancer. It is home to the largest collection of Phase 0 trials for brain tumors in the world. Our multidisciplinary team of brain tumor specialists and scientists are accelerating drug discovery and precision medicine in neuro-oncology to identify the most promising first-in-class therapies for brain tumor patients.

Job Description:
To develop brain targeting therapeutics via rational design and neuro-pharmacokinetic assessment through
preclinical and clinical studies.

Principal Duties and Responsibilities:
We are looking for an individual to join the Pharmacokinetics (PK) Lab as a postdoctoral associate. The candidate should have a strong background in chemical/pharmaceutical sciences with a reasonable working knowledge of translational research. Candidates who have experience in LC-MS/MS-based method development/validation and can demonstrate competency in pharmacokinetic data analysis will be preferred. The candidate should be able to work well in highly collaborative environment and have excellent communication skills. Potential areas of application include bioanalysis, medicinal chemistry, drug development, drug PK, organic synthesis, method validation, biomarker analysis, and PK modeling. The candidate is encouraged to apply for internal and external grants.

Key responsibilities include
 Development, validation and implementation of analytical methods for various drugs, drug candidates, metabolites, and biomarkers employing UHPLC and LC-MS/MS techniques.
 Performing pharmacokinetic data analyses.
 Manuscript preparation and publishing.
 Supervision and training of laboratory supporting research staff.
 Preparation and delivery of research presentations at local meetings, national and international conferences.
 General operation, maintenance, and troubleshooting of laboratory equipment, including UHPLC and LC- MS/MS instruments.
 Preparation and maintenance of required laboratory safety documentation and adherence to the guidelines and regulations in compliance with CAP/CLIA and HIPAA rules.

Required

• Ph.D., post-baccalaureate M.D. or D.Sc. degree or equivalent in a relevant field of endeavor and Laboratory or clinical research at the post-baccalaureate level with an interest in a faculty member's line of study, upon hire

Preferred Qualifications:
 Research experience in organic synthesis, bioanalysis, medicinal or pharmaceutical chemistry areas.
 Experience with UHPLC or LCMS-based assay development.
 Experience with rational drug design and development, physicochemical characterization.
 Experience in biomedical research (cellular techniques and animal handling).
 Experience with maintenance and troubleshooting of LC and MS systems.
 Good organizational and analytical skills.
 Ability to work independently and cohesively as part of a team.

Additional Requirements
 Recommendation letters

Education
 Ph.D. or equivalent degree (MD, DVM, PharmD, etc.) in Pharmaceutical Sciences, Chemistry, Biochemistry, Medical Sciences or in related disciplines.

Hello humankindness Located conveniently in the heart of Phoenix, Arizona,St. Joseph's Hospital and Medical Center is a 571-bed, not-for-profit hospital that provides a wide range of health, social and support services. Founded in 1895 by the Sisters of Mercy, St. Joseph's was the first hospital in the Phoenix area. More than 125 years later, St. Joseph's remains dedicated to its mission of caring for the poor and underserved. We are extremely proud to be a nationally recognized center for quality quaternary care, medical education and research. St. Joseph's includes the internationally renowned Barrow Neurological Institute, Norton Thoracic Institute, Cancer Center at St. Joseph's, Ivy Brain Tumor Center, and St. Joseph's Level I Trauma Center (which is verified by the American College of Surgeons). The hospital is also a respected center for high-risk obstetrics, neuro-rehabilitation, orthopedics, and other medical services. St. Joseph’s is considered a sought-after destination hospital for treating the most complex cases from throughout the world. Every day, approximately 20 percent of the hospital’s patients have traveled from outside of Arizona and the United States to seek treatment at St. Joseph’s. U.S News & World Report routinely ranks St. Joseph's among the top hospitals in the United States for neurology and neurosurgery. In addition, St. Joseph's boasts the Creighton University School of Medicine at St. Joseph's, and a strategic alliance with Phoenix Children's Hospital. St. Joseph's is consistently named an outstanding place to work and one of Arizona's healthiest employers. Come grow your career with one of Arizona's Most Admired Companies.

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